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Results for "

ELOVL1

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

1

Biochemical Assay Reagents

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-145272
    ELOVL1-IN-3
    1 Publications Verification

    		 ELOVL Neurological Disease
    ELOVL1-IN-3 (Compound 22) is a potent and orally active inhibitor of elongation of very long chain fatty acid 1 (ELOVL1) enzyme. ELOVL1-IN-3 serves as a useful tool for researching adrenoleukodystrophy (ALD) [1].
    ELOVL1-IN-3
  • HY-145270
    ELOVL1-IN-2

    		ELOVL Metabolic Disease
    ELOVL1-IN-2 is an elongation of very long chain fatty acid 1 (ELOVL1) enzyme inhibitor, ELOVL1-IN-2 shows weak ELOVL1 inhibition (IC50=21 μM) and moderate potency in a primary cellular assay (HEK293 C26 IC50=6.7 μM) [1].
    ELOVL1-IN-2
  • HY-W269593
    Perfluorodecanoic acid
    1 Publications Verification

    PFDA

    		 Caspase Interleukin Related Metabolic Disease
    Perfluorodecanoic acid (PFDA) is an orally active perfluoroalkyl substance. Perfluorodecanoic acid causes dysfunction of rat fetal Leydig cells via endoplasmic reticulum stress-mediated changes in lipid components. Perfluorodecanoic acid reduces testosterone biosynthesis in rat R2C Leydig cells by inducing endoplasmic reticulum stress. Perfluorodecanoic acid can be used in studies related to fetal Leydig cell dysfunction [1] .
    Perfluorodecanoic acid
  • HY-NP0204
    Mouse Serum Albumin

    		ELOVL Apoptosis NOD-like Receptor (NLR) Caspase Tau Protein Neurological Disease Inflammation/Immunology
    Mouse Serum Albumin is most abundant protein in plasma, which leaks into the brain parenchyma when the blood-brain barrier (BBB) is impaired. Mouse Serum Albumin induces astrocytes to A1 phenotype to remarkably increase levels of Elovl1. Mouse Serum Albumin promotes VLSFAs secretion and causes neuronal lippoapoptosis through endoplasmic reticulum stress response pathway. MSA-activated microglia triggeres remarkable tau phosphorylation at multiple sites (Ser202/Thr205) through NLRP3 inflammasome pathway. Mouse Serum Albumin decreases the spatial learning and memory abilities in mice. Mouse Serum Albumin can be used for the study of neurodegenerative diseases like Alzheimer’s disease (AD) and frontotemporal dementia (FTD) [1].
    Mouse Serum Albumin
  • HY-152947
    ELOVL6-IN-4

    		ELOVL Metabolic Disease
    ELOVL6-IN-4 is a potent, selective, and orally active long chain fatty acid elongase 6 (ELOVL6) inhibitor with IC50s of 79 nM and 94 nM for human and mouse ELOVL6, respectively. ELOVL6-IN-4 shows excellent selectivity over the other human ELOVL subtypes (ELOVL1, -2, -3, and -5) and mouse ELOVL3 [1].
    ELOVL6-IN-4
  • HY-145122
    ELOVL1-IN-1
    1 Publications Verification

    		 ELOVL Metabolic Disease
    ELOVL1-IN-1 is an ELOVL1 inhibitor extracted from patent WO2018107056A1, compound 87. ELOVL1-IN-1 can reduce very long chain fatty acid levels. ELOVL1-IN-1 can be used for the research of adrenoleukodystrophy (ALD) [1].
    ELOVL1-IN-1
  • HY-160912
    ELOVL6-IN-5

    		ELOVL Metabolic Disease
    ELOVL6-IN-5 is an orally active and selective elongase enzyme of long-chain fatty acid family 6 (ELOVL6) inhibitor with IC50 values of 85 nM and 38 nM for human and mouse ELOVL6, respectively. ELOVL6-IN-5 shows >60-fold selectivity over other ELOVL family enzymes (ELOVL1, 2, 3, 5) and no effect on other lipid synthesis enzymes like ACC1, ACC2. ELOVL6-IN-5 reduces hepatic fatty acid composition ratio of C18 to C16 in diet-induced obesity (DIO) and KKAy mice. ELOVL6 inhibition by ELOVL6-IN-5 does not improve insulin resistance. ELOVL6-IN-5 can be used for the research of metabolic disease [1].
    ELOVL6-IN-5
  • HY-RS18862
    Elovl1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Elovl1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Elovl1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Elovl1 Mouse Pre-designed siRNA Set A
    Elovl1 Mouse Pre-designed siRNA Set A
  • HY-RS25354
    Elovl1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Elovl1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Elovl1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Elovl1 Rat Pre-designed siRNA Set A
    Elovl1 Rat Pre-designed siRNA Set A
  • HY-RS04321
    ELOVL1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ELOVL1 Human Pre-designed siRNA Set A contains three designed siRNAs for ELOVL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ELOVL1 Human Pre-designed siRNA Set A
    ELOVL1 Human Pre-designed siRNA Set A

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