1 Result for "

ER-DNA

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "ER-DNA" in MCE Product Catalog:

Cat. No.: HY-141551
CAS No.: 2369048-69-9
Purity:  98.00%
Target:  

Estrogen Receptor/ERR

Research Areas:  

Cancer

GNE-274 is a structural analog of the ER degrader GDC-0927 and is a non-degrader. GNE-274 does not induce conversion of ER in breast cancer cell lines and functions as a partial ER agonist (partial ER agonist). GNE-274 increases the chromatin accessibility of ER-DNA binding sites, whereas GDC-0927 does not. GNE-274 is an effective ER ligand binding domain (LBD) inhibitor. GNE-274 can be used in cancer research.
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