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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
G469A
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "G469A" in MCE Product Catalog:
Synonyms: CFT1946
Tagarafdeg (CFT1946) is an orally active, CRBN-based and mutant-selective bifunctional degradation activating compound (BiDAC) degrader of BRAF V600E with a DC50 of 14 nM in A375 cells. Tagarafdeg is capable of degrading BRAF V600E (Class I), G469A (Class II), G466V (Class III) mutations, and the p61-BRAF V600E splice variant. Tagarafdeg can be used in tumor research .
Cat. No.: HY-159795
CAS No.: 2754408-94-9
Synonyms: PF-07799933; ARRY-440
Claturafenib ( PF-07799933) is an orally active inhibitor of pan-mutant BRAF. Claturafenib inhibits pERK in cells (IC50 value of 1.6 nM in HT29 cells). Claturafenib has anticancer activity against BRAF G469A mutant NSCLC and BRAF K601E mutant melanoma .
Cat. No.: HY-P10436
CAS No.: 2411851-64-2
Cat. No.: HY-P705738
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: BRAF; V-Raf Murine Sarcoma Viral Oncogene-Like Protein B1; B-Raf Proto-Oncogene, Serine/Threonine Kinase; Murine Sarcoma Viral (V-Raf) Oncogene Homolog B1; BRAF1; Serine/Threonine-Protein Kinase B-Raf Variant; BRAF-1; Non-Specific Serine/Threonine Protein
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
