2754408-94-9
2754408-94-9
Chemical Structure
Claturafenib
Synonym(s): PF-07799933; ARRY-440
- CAS No.: 2754408-94-9
- Formula:C18H15Cl2F2N5O3S
- Molecular Weight:490.31
InChIKey: SHENFUUACGRLOZ-UHFFFAOYSA-N
SMILES: O=C1C2=C(C=CC(NC3=C(Cl)C(NS(=O)(N4CC(C4)F)=O)=CC=C3F)=C2Cl)N=CN1C
Biological Activity: Claturafenib ( PF-07799933) is an orally active inhibitor of pan-mutant BRAF. Claturafenib inhibits pERK in cells (IC50 value of 1.6 nM in HT29 cells). Claturafenib has anticancer activity against BRAFG469A mutant NSCLC and BRAFK601E mutant melanoma[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Claturafenib | 99.95% | Claturafenib ( PF-07799933) is an orally active inhibitor of pan-mutant BRAF. Claturafenib inhibits pERK in cells (IC50 value of 1.6 nM in HT29 cells). Claturafenib has anticancer activity against BRAFG469A mutant NSCLC and BRAFK601E mutant melanoma. | ||||||||||||||||||||
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References
Keywords
