2 Results for "

GR73632

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "GR73632" in MCE Product Catalog:

Cat. No.: HY-P1192
CAS No.: 133156-06-6
Target:  

Neurokinin Receptor

Research Areas:  

Neurological Disease

GR-73632 is a tachykinin NK1 receptor agonist. GR-73632 activates spinal NK1 receptors to induce scratching, biting and licking behaviors. GR-73632 activates peripheral NK1 receptors to trigger lacrimation in guinea pigs, and activates central NK1 receptors to induce repetitive hind paw tapping behavior in gerbils. GR-73632 is applicable to research related to pruritus .
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Cat. No.: HY-12140
CAS No.: 334476-46-9
Synonyms: GW597599
Target:  

Neurokinin Receptor

Research Areas:  

Neurological Disease

Vestipitant (GW597599) is a neurokinin-1 receptor antagonist (pKi: 9.4, hNK1) with hypnotic effects and the ability to suppress primary insomnia. Vestipitant can effectively block substance P-mediated extracellular regulated kinase phosphorylation and relieve anxiety and possible depression induced by the agonist GR73632 (HY-P1192) in gerbils. Vestipitant can also improve functional dyspnea, anxiety, insomnia, irritable bowel disease, gastroesophageal reflux disease, tinnitus and antiemetic effects .
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