1 Result for "

HM279

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "HM279" in MCE Product Catalog:

Cat. No.: HY-185430
CAS No.: 3039954-64-5
Target:  

TGF-β Receptor

Research Areas:  

Inflammation/Immunology Cancer

HM-279 is a potent and orally active ALK5 inhibitor with an IC50 of 4.7 nM. HM-279 shows cross-reactivity with ALK7 (IC50 = 6.8 nM), but HM-279 has fair to good selectivity against other TGF-β receptor family kinases, with 4.5-693-fold selectivity. HM-279 demonstrates antitumor activity in vivo through CD8 + T cell immunity. HM-279 can be used for the research of colon cancer .
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