4 Results for "

Human IL13 mRNA

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "Human IL13 mRNA" in MCE Product Catalog:

Cat. No.: HY-174639
Target:  

mRNA

Research Areas:  

Inflammation/Immunology

Human IL13 mRNA encodes the human interleukin 13 (IL13) protein, an immunoregulatory cytokine produced primarily by activated Th2 cells. IL13 is involved in several stages of B-cell maturation and differentiation and is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils.
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Cat. No.: HY-P990093
CAS No.: 2734715-10-5
Synonyms: CM310

Research Areas:  

Inflammation/Immunology

Stapokibart (CM310) is a humanized monoclonal antibody targeting IL-4Rα (KD values of 0.25 nM, 1.50 nM, and 2.75 nM for human, cynomolgus monkey, and rat IL-4Rα, respectively). Stapokibart effectively blocks the interaction of cytokines IL-4 and IL-13 with their co-receptor subunit IL-4Rα. Stapokibart reduces IL-4 and IL-13 mRNA, inhibits CD23 upregulation, and inhibits IL-4 and IL-13-induced STAT6 activation. Stapokibart improves inflammation (airway inflammation, rhinitis, dermatitis) .
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Cat. No.: HY-174637
Target:  

mRNA

Research Areas:  

Inflammation/Immunology

Human IL13RA2 mRNA encodes the human interleukin 13 receptor subunit alpha 2 (IL13RA2) protein, a subuint of the interleukin 13 receptor complex. IL13RA2 binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13.
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Cat. No.: HY-174638
Target:  

mRNA

Research Areas:  

Inflammation/Immunology

Human IL13RA1 mRNA encodes the human interleukin 13 receptor subunit alpha 1 (IL13RA1) protein, a subunit of the interleukin 13 receptor. IL13RA1 serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. It has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.
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