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IC1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (1) Enterovirus (1) HIV (1) MEK (1) p38 MAPK (1) PERK (1) Phosphodiesterase (PDE) (1)
By Research Areas:	Cancer (2) Infection (3) Neurological Disease (1)

Inhibitors & Agonists

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-156625

Nedometinib 1 Publications Verification NFX-179	MEK PERK p38 MAPK	Cancer
Nedometinib (NFX-179) is a specific *MEK1* inhibitor with an IC₅₀ of 135 nM. Nedometinib inhibits p-ERK, MAPK. Nedometinib exerts anticancer activity against squamous cell carcinoma. Nedometinib can be used for research in dermatosis, neurofibromatosis ^[1] .

HY-129943

Benzothiohydrazide	Bacterial	Infection
Benzothiohydrazide is an analogue of anti–tubercular agent Isoniazid. Benzothiohydrazide exhibits anti–tubercular activity, with MICs of 132 μM and 264 μM for M. tuberculosis wild type (H37Rv) and clinical mutant strains (IC₁ and IC₂) ^[1].

HY-U00427

PDE2A-IN-3	Phosphodiesterase (PDE)	Neurological Disease Cancer
PDE2A-IN-3 (Example Ic1) is a selective phosphodiesterase 2A (PDE2A) inhibitor with IC₅₀s of 69 nM and 1762 nM for PDE2A and PDE10, respectively. PDE2A-IN-3 can be used for the study of neurological and psychiatric disorders ^[1].

HY-168525

IC-1k	HIV	Infection
IC-1k is a potent *HIV-1* inhibitor with EC₅₀ values of 2.69, 97.97 nM for HIV-1 IIIB, HIV-2 ROD, respectively. IC-1k shows cytotoxicity. IC-1k shows antiviral activity ^[1].

HY-148307

MDL-20610	Enterovirus	Infection
MDL-20610 is a potent antirhinovirus compound with an median plaque 50% inhibitory concentrations (IC_1/2) of 0.003 µg/mL. MDL-20610 also exhibits activity against human, simian, and bovine rotaviruses and possesses variable enterovirus and paramyxovirus activity. MDL-20610 can be used for antiviral research ^[1].

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P810415

	Dynein Intermediate Chain 1 Antibody (YA9730) Axonemal dynein intermediate chain 1, Axonemal dynein intermediate chain 2, CILD 1, CILD1, CytoplasmIC dynein 1 intermediate chain 1, CytoplasmIC dynein 1 intermediate chain 2, CytoplasmIC dynein intermediate chain 1, CytoplasmIC dynein intermediate chain 2, DH IC 1, DH IC 2	WB, IHC-P	Human, Rat, Mouse
	Dynein Intermediate Chain 1 Antibody (YA9730) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to Dynein Intermediate Chain 1.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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