1 Result for "

IC86621

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "IC86621" in MCE Product Catalog:

Cat. No.: HY-100707
CAS No.: 404009-40-1
Purity:  99.06%
Target:  

DNA-PK Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

IC 86621 is a potent DNA-dependent protein kinase (DNA-PK) inhibitor, with an IC50 of 120 nM. IC 86621 also acts as a selective and reversible ATP-competitive inhibitor.IC 86621 inhibits DNA-PK mediated cellular DNA double-strand break (DSB) repair (EC50=68 µM). IC 86621 increases DSB-induced antitumor activity without cytotoxic effects. IC 86621 can protects rheumatoid arthritis (RA) T cells from apoptosis .
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