404009-40-1
Chemical Structure
IC 86621
- CAS No.: 404009-40-1
- Formula:C12H15NO3
- Molecular Weight:221.25
IUPAC Name: 1-(2-hydroxy-4-morpholinophenyl)ethan-1-one
InChIKey: YHKSBKQXCWHTQL-UHFFFAOYSA-N
SMILES: CC(C1=CC=C(N2CCOCC2)C=C1O)=O
Biological Activity: IC 86621 is a potent DNA-dependent protein kinase (DNA-PK) inhibitor, with an IC50 of 120 nM. IC 86621 also acts as a selective and reversible ATP-competitive inhibitor.IC 86621 inhibits DNA-PK mediated cellular DNA double-strand break (DSB) repair (EC50=68 µM). IC 86621 increases DSB-induced antitumor activity without cytotoxic effects. IC 86621 can protects rheumatoid arthritis (RA) T cells from apoptosis[1][2].
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IC 86621 | 99.06% | IC 86621 is a potent DNA-dependent protein kinase (DNA-PK) inhibitor, with an IC50 of 120 nM. IC 86621 also acts as a selective and reversible ATP-competitive inhibitor.IC 86621 inhibits DNA-PK mediated cellular DNA double-strand break (DSB) repair (EC50=68 µM). IC 86621 increases DSB-induced antitumor activity without cytotoxic effects. IC 86621 can protects rheumatoid arthritis (RA) T cells from apoptosis. | ||||||||||||||||||||
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- [1]. Chandra G, et al. Improved synthesis of a DNA-dependent protein kinase inhibitor IC86621. Arch Pharm Res. 2012 Mar;35(4):639-45. [Content Brief]
- [2]. Shao L, et al. DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis. EMBO Mol Med. 2010 Oct;2(10):415-27. [Content Brief]
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