8 Results for "

IRP1

" in MedChemExpress (MCE) Product Catalog:
Products (8)

8 Results for "IRP1" in MCE Product Catalog:

1
Kumatakenin
Kumatakenin
0 Images
1 Cited Publications
Cat. No.: HY-N3415
CAS No.: 3301-49-3
Category:  

Flavonols Flavonoids Myrtaceae Phenols Polyphenols Plants Disease Research Fields Syzygium aromaticum Cancer

Target:  

Apoptosis Autophagy Caspase Ferroptosis SARS-CoV

Kumatakenin is an orally active apoptosis inducer and autophagy inhibitor, with a Kd value of 2.94 μM for mouse ATG5. Kumatakenin increases the activities of caspase-3, caspase-8 and caspase-9, thereby inducing caspase-dependent apoptosis in ovarian cancer cells. Kumatakenin reduces the expression of chemokines and pro-oncogenic factors in ovarian cancer cells, and inhibits M2 macrophage polarization. Kumatakenin inactivates TRIM65 function, reduces the expression and stability of FASN, and thus inhibits the proliferation, migration, invasion and tumor progression of esophageal cancer cells. Kumatakenin interacts with ATG5 to reduce its protein level, decrease LC3 level, and reduce the number of autophagosomes in the hippocampus. Kumatakenin binds to Eno3 to upregulate its expression, reduce the stability and expression level of IRP1 mRNA, inhibit ferroptosis, alleviate intestinal inflammation, and restore epithelial barrier function. Kumatakenin enhances the efficacy of antibiotics against pathogenic bacteria, inhibits SARS-CoV-2 replication, and reduces cytokine production. Kumatakenin is applicable to research related to ovarian cancer, esophageal cancer, depression and colitis [1] .
Aconitase 1/ACO1 Protein, Human (sf9, His)
Aconitase 1/ACO1 Protein, Human (sf9, His)
0 Images
Cat. No.: HY-P75560
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Cytoplasmic aconitate hydratase; Aconitase; IRP1; IRE-BP 1; ACO1; IREB1
Species:  
Human
Source:  
Sf9 insect cells
ACO1 Human Pre-designed siRNA Set A
ACO1 Human Pre-designed siRNA Set A
Cat. No.: HY-RS00170
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

ACO1 Human Pre-designed siRNA Set A contains three designed siRNAs for ACO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Aconitase 1 Antibody (YA2850)
Aconitase 1 Antibody (YA2850)
0 Images
Cat. No.: HY-P83105
Synonyms: ACO1; IREB1; Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1

Host:  

Rabbit

Application:  

WB, ICC/IF

Reactivity:  

Human, Mouse, Rat

Phospho-Aconitase 1 (Ser138) Antibody
Phospho-Aconitase 1 (Ser138) Antibody
0 Images
Cat. No.: HY-P811169
Synonyms: IREB1, ACO1, Cytoplasmic aconitate hydratase, Aconitase, Citrate hydro-lyase, Ferritin repressor protein, Iron regulatory protein 1, Iron-responsive element-binding protein 1, IRP1, IRE-BP 1

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF

Reactivity:  

Human, Mouse, Rat

Aco1 Mouse Pre-designed siRNA Set A
Aco1 Mouse Pre-designed siRNA Set A
Cat. No.: HY-RS18459
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

Aco1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Aco1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Aco1 Rat Pre-designed siRNA Set A
Aco1 Rat Pre-designed siRNA Set A
Cat. No.: HY-RS24940
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

Aco1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Aco1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Aco2 Mouse Pre-designed siRNA Set A
Aco2 Mouse Pre-designed siRNA Set A
Cat. No.: HY-RS18460
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

Aco2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Aco2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Assay Types