3 Results for "

Imatinib-d8

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Imatinib-d8" in MCE Product Catalog:

1
Imatinib-d8
Imatinib-d8
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1 Cited Publications
Cat. No.: HY-15463S
CAS No.: 1092942-82-9
Purity:  99.85%
Synonyms: STI571-d8; CGP-57148B-d8
Imatinib-d8 is a deuterium labeled Imatinib (STI571). Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity .
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1
Imatinib-d8 mesylate
Imatinib-d8 mesylate
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1 Cited Publications
Cat. No.: HY-132386S
CAS No.: 1092942-83-0
Synonyms: STI571-d8 mesylate; CGP-57148B-d8 mesylate
Imatinib-d8 (mesylate) is the deuterium labeled Imatinib mesylate .
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N-Desmethyl imatinib-d8
N-Desmethyl imatinib-d8
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Cat. No.: HY-G0017S
CAS No.: 1185103-28-9
Synonyms: NorImatinib-d8; Imatinib metabolite N-Desmethyl Imatinib-d8; CGP 74588-d8
N-Desmethyl imatinib-d8 is a deuterium labeled Imatinib metabolite N-Desmethyl Imatinib (HY-G0017). N‑Desmethyl imatinib (Norimatinib) is an active metabolite of Imatinib (HY-15463), a selective c‑Abl inhibitor, and a substrate of P‑glycoprotein. N-Desmethyl imatinib binds to the c-Abl catalytic domain to prevent substrate phosphorylation, inhibits c-Abl-mediated α-synuclein activation and downstream inflammatory signaling pathways. N-Desmethyl imatinib induces apoptosis in K562 human leukemia cells. N-Desmethyl imatinib exhibits significantly elevated plasma levels in gastrointestinal stromal tumor (GIST) settings following mild SARS CoV 2 infection. N-Desmethyl imatinib can be used for the research of Parkinson’s disease, gastrointestinal stromal tumor, and chronic myeloid leukemia .
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