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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
JMJD1C
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "JMJD1C" in MCE Product Catalog:
Art. -Nr.: HY-162275
CAS. Nr.: 861224-48-8
Forschungsgebiete:
JMJD1C-IN-1 is an orally active and selective inhibitor of JMJD1C (IC50 = 0.59 μM, Kd = 1.96 μM). JMJD1C-IN-1 inhibits the binding of JMJD1C to H3K9me2 peptide substrate in the HTRF assay (IC50 = 1.47 μM). JMJD1C-IN-1 disrupts intratumoral regulatory T (Treg) cell fitness by dual mechanisms: promoting H3K9me2 accumulation to downregulate PD1 expression and reducing STAT3 demethylation to enhance STAT3 activation. JMJD1C-IN-1 demonstrates dose-dependent antitumor efficacy in multiple mouse tumor models (MCA205 fibrosarcoma, B16-F10 melanoma, LLC lung cancer, Hepa1-6 hepatocellular carcinoma, CT26 colorectal cancer). JMJD1C-IN-1 can be used for the study of tumor immunotherapy by selectively targeting intratumoral Treg cells [1].
Art. -Nr.: HY-RS07037
Target:
Forschungsgebiete:
JMJD1C Human Pre-designed siRNA Set A contains three designed siRNAs for JMJD1C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS16249
Target:
Forschungsgebiete:
Jmjd1c Mouse Pre-designed siRNA Set A contains three designed siRNAs for Jmjd1c gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS24674
Target:
Forschungsgebiete:
Jmjd1c Rat Pre-designed siRNA Set A contains three designed siRNAs for Jmjd1c gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-P71548
Reinheit: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: JMJD1C; TR-Interacting Protein 8; Prev. TRIP8; DKFZp761F0118; KDM3C; FLJ14374; Jumonji Domain-Containing Protein 1C; TRIP-8; KIAA1380; Putative JmjC Domain-Containing Histone Demethylation Protein 2C; Probable JmjC Domain-Containing Histone Demethylation
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
