1 Result for "

JMW-3B3

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "JMW-3B3" in MCE Product Catalog:

Cat. No.: HY-P991959

Target:  

CTLA-4

Research Areas:  

Inflammation/Immunology Cancer

JMW-3B3 is a humanized IgG1λ monoclonal antibody targeting CTLA-4. JMW-3B3 selectively binds the unique C-terminal sequence of sCTLA-4 to block its immunoregulatory and immunosuppressive activity without cross-reacting with full-length CTLA-4 receptor. JMW-3B3 enhances cytokine profiles in PBMC cultures responding to lupus autoantigen-derived peptides. JMW-3B3 enhances IFN-γ production in anti-CD3 stimulated PBMC from melanoma patients at low anti-CD3 doses. JMW-3B3 can be used for the research of systemic lupus erythematosus and malignant melanoma.
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