1 Result for "

JTX8064

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "JTX8064" in MCE Product Catalog:

Polzastobart
Polzastobart
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Referencia número: HY-P990061
No. CAS: 2640981-19-5
Synonyms: JTX 8064

Target:  

Transmembrane Glycoprotein LILRB

Áreas de investigación:  

Inflammation/Immunology Cancer

Polzastobart (JTX-8064) is a humanized IgG4 monoclonal antibody and LILRB2 (ILT4) antagonist. Polzastobart specifically binds to and antagonizes LILRB2, relieves ILT4-mediated myeloid immunosuppression, and promotes the polarization of macrophages from an M2-like phenotype to an M1-like phenotype. Polzastobart induces macrophage polarization, IFNγ signaling, and T cell inflammation-related pharmacodynamic responses in ex vivo human renal cancer, lung cancer, and head and neck cancer tissues. Polzastobart can be used in studies related to tumor-associated macrophages and tumor immunity. For the isotype control of Polzastobart, refer to: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
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