1 Result for "

KKL55

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "KKL55" in MCE Product Catalog:

Cat. No.: HY-183851
CAS No.: 639048-45-6
Target:  

Bacterial mRNA

Research Areas:  

Infection

KKL-55 is a broad-spectrum antibacterial agent that inhibits the trans-translation pathway and the ClpXP protease. KKL-55 suppresses trans-translation of non-stop mRNA, interferes with the binding of EF-Tu to tmRNA, and inhibits the proteolysis of substrates by ClpXP. KKL-55 blocks spore germination of Bacillus anthracis and protects macrophages from damage induced by anthrax toxin. By virtue of its inhibitory effect on ClpXP, KKL-55 synergistically enhances the antibacterial activity of antibiotics against drug-resistant Staphylococcus aureus. KKL-55 can be used in studies related to bacterial infections .
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