1 Result for "

KRM-III

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "KRM-III" in MCE Product Catalog:

Cat. No.: HY-136427
CAS No.: 79220-94-3
Purity:  98.08%
KRM-III is an orally active TCR inhibitor and NFAT inhibitor with an IC50 of 5 μM against NFAT. KRM-III has no effect on the activation of nuclear factor-κB. KRM-III inhibits T cell proliferation induced by T cell antigen receptor stimulation. KRM-III abrogates anti-CD3 antibody-induced cell activation in vivo. KRM-III reduces paw pad swelling in delayed-type hypersensitivity induced by Bovine serum albumin (HY-D0842). KRM-III alleviates the severity of experimental autoimmune encephalomyelitis (EAE) in mice. KRM-III can be used in studies related to experimental autoimmune encephalomyelitis .
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