79220-94-3
Chemical Structure
KRM-III
- CAS 番号: 79220-94-3
- Formula:C15H12N2S
- Molecular Weight:252.33
IUPAC Name: 1,4-diphenyl-1,3-dihydro-2H-imidazole-2-thione
InChIKey: QKOAQVKXZJFMET-UHFFFAOYSA-N
SMILES: S=C1NC(C2=CC=CC=C2)=CN1C3=CC=CC=C3
Biological Activity: KRM-III is an orally active TCR inhibitor and NFAT inhibitor with an IC50 of 5 μM against NFAT. KRM-III has no effect on the activation of NF-κB. KRM-III inhibits T cell proliferation induced by T cell antigen receptor stimulation. KRM-III abrogates anti-CD3 antibody-induced cell activation in vivo. KRM-III reduces paw pad swelling in delayed-type hypersensitivity induced by Bovine serum albumin (HY-D0842). KRM-III alleviates the severity of experimental autoimmune encephalomyelitis (EAE) in mice. KRM-III can be used in studies related to experimental autoimmune encephalomyelitis[1][2].
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KRM-III | 98.08% | KRM-III is an orally active TCR inhibitor and NFAT inhibitor with an IC50 of 5 μM against NFAT. KRM-III has no effect on the activation of NF-κB. KRM-III inhibits T cell proliferation induced by T cell antigen receptor stimulation. KRM-III abrogates anti-CD3 antibody-induced cell activation in vivo. KRM-III reduces paw pad swelling in delayed-type hypersensitivity induced by Bovine serum albumin (HY-D0842). KRM-III alleviates the severity of experimental autoimmune encephalomyelitis (EAE) in mice. KRM-III can be used in studies related to experimental autoimmune encephalomyelitis. | ||||||||||||||||||||
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References
- [1]. Jung EJ, et al. Oral administration of 1,4-aryl-2-mercaptoimidazole inhibits T-cell proliferation and reduces clinical severity in the murine experimental autoimmune encephalomyelitis model. The Journal of pharmacology and experimental therapeutics. 2009 Dec;331(3):1005-13. [Content Brief]
- [2]. Yellol G S, et al. Microwave‐Enhanced Efficient Regioselective Synthesis of 1, 3, 4‐Trisubstituted 2‐Mercaptoimidazoles on a Soluble Support[J]. Advanced Synthesis & Catalysis, 2012, 354(1): 187-196.
