1 Result for "

LSN 3353871

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "LSN 3353871" in MCE Product Catalog:

Cat. No.: HY-158424
CAS No.: 2565657-20-5
Purity:  99.62%
Target:  

LDLR

Research Areas:  

Cardiovascular Disease

LSN3353871 is an orally active inhibitor of lipoprotein (a) (Lp (a)) formation, with Kd values of 756 nM (apo (a) KIV8), 605 nM (apo (a) KIV7-8), and 423 nM (apo (a) KIV5-8), respectively, and an IC50 of 1.69 μM against apo (a) KIV5-8. LSN3353871 reduces circulating Lp (a) levels in transgenic mice and cynomolgus monkeys. LSN3353871 can be used in the research of atherosclerotic cardiovascular disease and calcific aortic valve disease .
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