3 Results for "

MMEJ

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "MMEJ" in MCE Product Catalog:

3
ART812
ART812
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3 Cited Publications
Cat. No.: HY-139289
CAS No.: 2607138-82-7
Purity:  99.90%
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

ART812 is an orally active DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM. ART812 has an IC50 value of 240 nM for cell based microhomology-mediated end joining (MMEJ) .
AZD4956
AZD4956
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Cat. No.: HY-183630
CAS No.: 3045469-78-8
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

AZD4956 is a potent and selective DNA polymerase theta (POLQ) inhibitor. AZD4956 exhibits an IC50 value of less than 3 μmol/L against POLQ and 3.4 μmol/L against MMEJ. AZD4956 suppresses the MMEJ pathway and enhances the activity of DNA-damaging agents in HRR-deficient cellular contexts. AZD4956 shows antitumor activity in BRCA1/2-mutated triple-negative breast cancer and prostate cancer models. AZD4956 can be used for the study of homologous recombination-deficient tumors .
SY-589
SY-589
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Cat. No.: HY-181557
CAS No.: 3077714-09-8
Target:  

DNA Alkylator/Crosslinker DNA/RNA Synthesis Apoptosis

Research Areas:  

Cancer

SY-589 is an orally active DNA polymerase Polθ helicase domain inhibitor (IC50=2.29 nM) and DNA damage inducer. SY-589 inhibits the ATPase activity of the Polθ helicase domain and blocks the Polθ-mediated microhomology-mediated end joining (MMEJ) DNA repair pathway (IC50=0.85 nM). SY-589 also induces the accumulation of DNA double-strand breaks by increasing γ-H2AX levels. SY-589 exerts antiproliferative effects on BRCA2-deficient cells and is used in the research of HR-deficient tumors .
Assay Types