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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
MS479
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "MS479" in MCE Product Catalog:
Cat. No.: HY-176035
Target:
Research Areas:
MS479 is a BRD4 PROTAC degrader. MS479 binds BRD4-BD2 and GLP with high affinities (BRD4-BD2: Kd = 200 nM; GLP: Kd = 306 nM). MS479 can reduce the protein level of BRD4 short isoform. MS479 recruits the E3 ligase SPOP by directly binding its substrate GLP as a bridge protein. MS479 can be used to inhibit the proliferation of colorectal cancer cells .
Cat. No.: HY-176037
Target:
Research Areas:
Boc-C3-amide-C10-amine is a PROTAC linker that can be used in the synthesis of PROTAC MS479 (HY-176035) .
Cat. No.: HY-176038
Research Areas:
MS1262-C3-amide-C10-amine is a E3 Ligase Ligand-Linker Conjugates. MS1262-C3-amide-C10-amine incorporates a GLP ligand for the E3 ligase SPOP (HY-176036), and a PROTAC linker (HY-176037). MS1262-C3-amide-C10-amine can be used to design PROTACs such as MS479 (HY-176035) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
