1 Result for "

NAB815

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "NAB815" in MCE Product Catalog:

NAB815
NAB815
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Cat. No.: HY-P11232
CAS No.: 1969250-99-4
Target:  

Toll-like Receptor (TLR) Bacterial

Research Areas:  

Infection

NAB815 is a specific inhibitor of the Stx2a (Kd = 0.01 μM)/TLR4 interaction. NAB815 inhibits the neutrophil/Stx2a interaction (IC50 = 0.057 μg/mL). NAB815 inhibits the formation of Stx2-containing extracellular vesicles (EVs) produced by leukocytes and platelets and reduces their toxic effects in cellular (Vero cells) and animal models (CD-1 mice). NAB815 reduces bacterial loads in the kidneys, urine, and bladders of Escherichia coli-infected mice. NAB815 is useful in the study of hemolytic uremic syndrome (HUS) .
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