1 Result for "

NC1153

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "NC1153" in MCE Product Catalog:

Cat. No.: HY-115464
CAS No.: 150661-91-9
Target:  

Endogenous Metabolite

Research Areas:  

Inflammation/Immunology

NC1153 is a Mannich base with the activity to block IL-2-induced JAK3 activation and its downstream substrate STAT5a/b. NC1153 effectively prolongs the survival of kidney transplants in MHC/non-MHC mismatched rats. NC1153 promotes long-term graft survival and includes multiple toxicity protection for recipients. NC1153 combined with cyclosporine A (CsA) can synergistically prolong graft survival without producing nephrotoxicity, myelotoxicity or lipotoxicity .
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