150661-91-9
Chemical Structure
NC1153
- CAS. Nr.: 150661-91-9
- Formula:C18H38Cl2N2O
- Molecular Weight:369.41
IUPAC Name: 2,12-bis((dimethylamino)methyl)cyclododecan-1-one dihydrochloride
InChIKey: GHMOOTNSJIQWGK-UHFFFAOYSA-N
SMILES: O=C1C(CN(C)C)CCCCCCCCCC1CN(C)C.Cl.Cl
Biological Activity: NC1153 is a Mannich base with the activity to block IL-2-induced JAK3 activation and its downstream substrate STAT5a/b. NC1153 effectively prolongs the survival of kidney transplants in MHC/non-MHC mismatched rats. NC1153 promotes long-term graft survival and includes multiple toxicity protection for recipients. NC1153 combined with cyclosporine A (CsA) can synergistically prolong graft survival without producing nephrotoxicity, myelotoxicity or lipotoxicity[1].
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NC1153 | NC1153 is a Mannich base with the activity to block IL-2-induced JAK3 activation and its downstream substrate STAT5a/b. NC1153 effectively prolongs the survival of kidney transplants in MHC/non-MHC mismatched rats. NC1153 promotes long-term graft survival and includes multiple toxicity protection for recipients. NC1153 combined with cyclosporine A (CsA) can synergistically prolong graft survival without producing nephrotoxicity, myelotoxicity or lipotoxicity. | |||||||||||||||||||||
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