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Results for "

NGF/bNGF

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Neurokinin Receptor (1) TNF Receptor (1) Trk Receptor (6)
By Research Areas:	Inflammation/Immunology (6) Neurological Disease (2)

Inhibitors & Agonists

Inhibitory Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P990474

*Anti-NGF/bNGF* Antibody** AS2886401-00	Trk Receptor	Inflammation/Immunology
Anti-NGF/bNGF Antibody is a CHO-expressed humanized antibody that targets *NGF/bNGF. Anti-NGF/bNGF* Antibody has a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 144.14 kDa. The isotype control for Anti-NGF/bNGF Antibody can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P991711

Povovetug	Trk Receptor	Neurological Disease Inflammation/Immunology
Povovetug is a humanized IgG1κ chimeric monoclonal antibody inhibitor targeting *NGF/bNGF*. Povovetug has a significant analgesic activity. Povovetug can be used for central neuroinflammation like chronic radicular pain research .

HY-P991324

MEDI-7352	Trk Receptor TNF Receptor	Inflammation/Immunology
MEDI-7352 is a human bispecific antibody (bsAb) targeting NGF/bNGF & TNF. MEDI-7352 can be used in osteoarthritis (OA) pain research .

HY-P991325

CRB-0089	Trk Receptor	Inflammation/Immunology
CRB-0089 is a human monoclonal antibody (mAb) targeting *NGF/bNGF*. CRB-0089 can be used in analgesia research.

HY-P991323

MEDI-1912	Trk Receptor Neurokinin Receptor	Inflammation/Immunology
MEDI-1912 is a human monoclonal antibody (mAb) targeting *NGF/bNGF. MEDI-1912 inhibits signaling through TrkA* and p75 receptors. MEDI-1912 can be used in chronic pain research .

HY-P992345

DS002	Trk Receptor	Neurological Disease
DS002 is a human monoclonal antibody targeting *NGF/bNGF, with an IC₅₀* of 6.60 nM against human *NGF, 1.98 nM against rat NGF, and 8.46 nM against mouse NGF. DS002 blocks NGF-TrkA* binding, interrupts pain signal transduction, inhibits TrkA-mediated downstream signaling pathways, and alters aromatic amino acid metabolic pathways. DS002 inhibits cancer cell proliferation. DS002 exerts a preventive effect on Paclitaxel-, Cisplatin- and Vincristine-induced peripheral neuropathy in rats. DS002 can be used in studies related to chronic pain and chemotherapy-induced peripheral neuropathy .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990474

*Anti-NGF/bNGF* Antibody** AS2886401-00	Trk Receptor	Inflammation/Immunology
Anti-NGF/bNGF Antibody is a CHO-expressed humanized antibody that targets *NGF/bNGF. Anti-NGF/bNGF* Antibody has a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 144.14 kDa. The isotype control for Anti-NGF/bNGF Antibody can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P991711

Povovetug	Trk Receptor	Neurological Disease Inflammation/Immunology
Povovetug is a humanized IgG1κ chimeric monoclonal antibody inhibitor targeting *NGF/bNGF*. Povovetug has a significant analgesic activity. Povovetug can be used for central neuroinflammation like chronic radicular pain research .

HY-P991324

MEDI-7352	Trk Receptor TNF Receptor	Inflammation/Immunology
MEDI-7352 is a human bispecific antibody (bsAb) targeting NGF/bNGF & TNF. MEDI-7352 can be used in osteoarthritis (OA) pain research .

HY-P991325

CRB-0089	Trk Receptor	Inflammation/Immunology
CRB-0089 is a human monoclonal antibody (mAb) targeting *NGF/bNGF*. CRB-0089 can be used in analgesia research.

HY-P991323

MEDI-1912	Trk Receptor Neurokinin Receptor	Inflammation/Immunology
MEDI-1912 is a human monoclonal antibody (mAb) targeting *NGF/bNGF. MEDI-1912 inhibits signaling through TrkA* and p75 receptors. MEDI-1912 can be used in chronic pain research .

HY-P992345

DS002	Trk Receptor	Neurological Disease
DS002 is a human monoclonal antibody targeting *NGF/bNGF, with an IC₅₀* of 6.60 nM against human *NGF, 1.98 nM against rat NGF, and 8.46 nM against mouse NGF. DS002 blocks NGF-TrkA* binding, interrupts pain signal transduction, inhibits TrkA-mediated downstream signaling pathways, and alters aromatic amino acid metabolic pathways. DS002 inhibits cancer cell proliferation. DS002 exerts a preventive effect on Paclitaxel-, Cisplatin- and Vincristine-induced peripheral neuropathy in rats. DS002 can be used in studies related to chronic pain and chemotherapy-induced peripheral neuropathy .

HY-P990629

MEDI-578	Inhibitory Antibodies	Inflammation/Immunology
MEDI-578 is a CHO-expressed human antibody that targets *NGF/bNGF*. MEDI-578 has a huIgG2a heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for MEDI-578 can be referenced as Human IgG4 kappa, Isotype Control (HY-P99003).

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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