1 Result for "

NSC-368262

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "NSC-368262" in MCE Product Catalog:

Cat. No.: HY-120031
CAS No.: 299421-08-2
Target:  

STAT PARP Apoptosis

Research Areas:  

Cancer

NSC-368262 is a STAT3 inhibitor. NSC-368262 selectively alkylates and covalently modifies STAT3 Cys468 at the DNA-binding interface of STAT3, blocks the DNA-binding activity of STAT3, and inhibits the phosphorylation of STAT3. NSC-368262 blocks the accumulation of activated STAT3 in the nucleus of cancer cells, induces PARP cleavage and apoptosis in cells, and inhibits tumor growth in mouse models. NSC-368262 can be used in research related to breast cancer and cervical cancer .
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