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Results for "

OPRM1

" in MedChemExpress (MCE) Product Catalog:

3

Inhibitors & Agonists

1

Natural
Products

1

Recombinant Proteins

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-RS09806
    OPRM1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    OPRM1 Human Pre-designed siRNA Set A contains three designed siRNAs for OPRM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    OPRM1 Human Pre-designed siRNA Set A
    OPRM1 Human Pre-designed siRNA Set A
  • HY-13906
    Largazole

    (+)-Largazole

    		 HDAC Neurological Disease Cancer
    Largazole ((+)-Largazole) is a potent, selective, orally active and brain-penetrant class I HDAC inhibitor found in marine cyanobacteria. Largazole shows an IC50 of 0.07 nM for HDAC2. Largazole releases its active form Largazole thiol (HY-170890) after hydrolysis. Largazole has a strong inhibitory effect on SF-268, SF-295 and SH-SY5Y cells, with IC50 values of 62, 68 and 102 nM respectively Largazole can upregulate the tumor suppressor gene Pax6 to inhibit the proliferation, invasion and colony formation of glioblastoma cells. Largazole can significantly upregulated brain-derived neurotrophic factor BDNF, neuronal transcription factor Pax6, and μ-opioid receptor gene Oprm1. Largazole exerts antitumor and neuroprotective effects. Largazole can be used for researches of Glioblastoma and Alzheimer’s disease [1].
    Largazole
  • HY-116163
    ML350

    CYM50202

    		 Endogenous Metabolite Others
    ML350 (CYM50202) is a highly potent OPRK1 antagonist with selectivity and broad biological applications. With IC50 values of 9-16 nM, ML350 shows high selectivity for OPRK1, with selectivity of 219-382-fold and 20-35-fold relative to OPRD1 and OPRM1, respectively. ML350 exhibited favorable characteristics in in vivo pharmacokinetic analysis, including high passive membrane permeability and moderate human plasma protein binding. Extensive screening of ML350 against multiple ion channels, receptors, and transporters showed that it does not have adverse off-target effects [1].
    ML350

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