2 Results for "

OSTβ

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "OSTβ" in MCE Product Catalog:

Cat. No.: HY-N4067
CAS No.: 566-24-5
Synonyms: isoCDCA
Category:  

Natural Products

Isochenodeoxycholic acid (isoCDCA) is a FXR agonist. Isochenodeoxycholic acid activates the activity of FXR and induces the mRNA expression of FXR target genes (Ostβ and Kng1). Isochenodeoxycholic acid serves as a substrate for the liver class I ADH γγ isozyme-mediated 3β-dehydrogenation reaction .
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Cat. No.: HY-179703
CAS No.: 2991276-14-1
Target:  

FXR

Research Areas:  

Inflammation/Immunology

FXR agonist 15 is a selective, potent and orally active farnesoid X receptor (FXR) agonist with EC50 of 0.76 μM. FXR agonist 15 exhibits no obvious activation on other nuclear receptors including LXRα/β, PXR, PPARα/β/γ, THR-β, with EC50 values all >10 μM. FXR agonist 15 can alleviate steatosis, lobular inflammation, hepatocyte ballooning and liver fibrosis. FXR agonist 15 can be used for the research of nonalcoholic steatohepatitis (NASH) .
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