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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
OTC
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "OTC" in MCE Product Catalog:
Target:
Research Areas:
4-Epioxytetracycline, the degradation product of Oxytetracycline (OTC), can be found in swine manure compost and wastewater .
Cat. No.: HY-125947R
CAS No.: 14206-58-7
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4-Epioxytetracycline (Standard) is the analytical standard of 4-Epioxytetracycline. This product is intended for research and analytical applications. 4-Epioxytetracycline, the degradation product of Oxytetracycline (OTC), can be found in swine manure compost and wastewater .
Cat. No.: HY-RS09859
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OTC Human Pre-designed siRNA Set A contains three designed siRNAs for OTC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17937
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Otc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Otc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24408
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Otc Rat Pre-designed siRNA Set A contains three designed siRNAs for Otc gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P81485A
Synonyms: OTCase; Ornithine carbamoyltransferase; mitochondrial; OCTD
Cat. No.: HY-L076
641 compounds
Drug-induced liver injury (DILI; also known as drug-induced hepatotoxicity) is caused by medications (prescription or OTC), herbal and dietary supplements (HDS), or other xenobiotics that result in abnormalities in liver tests or in hepatic dysfunction that cannot be explained by other causes. Drugs are an important cause of liver injury. Drug-induced hepatic injury is the most common reason cited for withdrawal of an approved drug.
DILI is thought to occur via several different mechanisms. Among these are direct impairment of the structural (e.g., mitochondrial dysfunction) and functional integrity of the liver; production of a metabolite that alters hepatocellular structure and function; production of a reactive drug metabolite that binds to hepatic proteins to produce new antigenic drug-protein adducts, which are targeted by hosts’ defenses (the hapten hypothesis); and initiation of a systemic hypersensitivity response (i.e., drug allergy) that damages the liver.
MCE Drug-induced Liver Injury (DILI) Compound Library contains a unique collection of 641 hepatotoxicity causing compounds and is a powerful tool to research DILI and other drug toxicities. This library can be used to understand the mechanisms of DILI, identify biomarkers for early DILI prediction, and allow timely recognition during drug development, thus finally achieving successful DILI prevention and assessment in the pre-marketing phase.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
