1 Result for "

PF 303

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "PF 303" in MCE Product Catalog:

Cat. No.: HY-164002
CAS No.: 1609465-78-2
Target:  

Btk

Research Areas:  

Others

PF-303 is a potent, oral inhibitor of Bruton's tyrosine kinase (BTK) (IC50=0.64 nM). The melamine portion of PF-303 forms a covalent bond with BTK's Cys481, which is reversible and exhibits a high selectivity compared to irreversible covalent BTK inhibitors. PF-303 can be used to model and study the effects of BTK inhibition on the mature immune system, including effects on B-cell subsets, antibody responses, and T-cell-mediated activation .
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