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Pathways Recommended:	PI3K/Akt/mTOR

Results for "

PI(3,4)P2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (2) Endogenous Metabolite (1) PI3K (3)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Metabolic Disease (3)
Oligonucleotides:	Phospholipids (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124535

TGX-115	PI3K	Metabolic Disease
TGX-115 is a p110β/p110δ-selective, PI3-K inhibitor. TGX-115 blocks p110β-mediated Akt phosphorylation induced by lysophosphatidic acid (LPA) in L6 myotubes, reduces insulin-stimulated *PI(3,4)P2* and PIP3 levels in 3T3-L1 adipocytes. TGX-115 can be used for the study of diabetes mellitus .

HY-157706

PI(3,4)P2 (18:1) ammonium salt	PI3K	Cardiovascular Disease Metabolic Disease Cancer
PI(3,4)P2 (18:1) ammonium salt is a phosphatidylinositol 3 kinase (PI3K) activator. PI(3,4)P2 (18:1) ammonium salt is a polyphosphorylated phosphatidylinositol that promotes the activation of AKT (protein kinase B) by activating PI3K, which affects cell metabolism, growth and survival. PI(3,4)P2 (18:1) ammonium salt is also involved in regulating dynamic changes in the cytoskeleton, affecting cell morphology and movement. PI(3,4)P2 (18:1) ammonium salt can be used in research on the development of cancer, diabetes and cardiovascular disease .

HY-176832

PtdIns-(3,4)-P2 (1,2-dipalmitoyl) sodium PI(3,4)P2 (16:0/16:0) sodium; PIP2[3',4'](16:0/16:0) sodium; Phosphatidylinositol-3,4-diphosphate C-16 sodium	Endogenous Metabolite	Others
PtdIns-(3,4)-P2 (1,2-dipalmitoyl) (PI(3,4)P2 (16:0/16:0)) sodium is a phosphatidylinositol .

HY-172742

*Dioctanoyl PI(3,4)P2* sodium**	Biochemical Assay Reagents	Others
Dioctanoyl PI(3,4)P2 (sodium) is a synthetic analog of natural Ptdlns featuring C8:0 fatty acids at the sn-1 and sn-2 positions. Dioctanoyl PI(3,4)P2 (sodium) contains the same inositol and diacylglycerol (DAG) stereochemistry as the natural Ptdlns .

HY-178371

PI3KC2γ-IN-1	PI3K	Metabolic Disease
PI3KC2γ-IN-1 (Compound 23) is an orally active and selective PI3KC2γ inhibitor (IC₅₀ = 4 nM). PI3KC2γ-IN-1 downregulats the Akt2-glycogen synthase (GS) signaling pathway, ultimately inhibiting the conversion of glucose to glycogen and reduces excessive glycogen accumulation in the liver. PI3KC2γ-IN-1 can significantly inhibit insulin-induced PI(3,4)P₂ accumulation in both primary hepatocytes and HepG2 liver cancer cells. PI3KC2γ-IN-1 can be used for the study of glycogen storage diseases (GSDs) .

HY-157714

08:0 PI(3,4)P2 1,2-Dioctanoyl-sn-glycero-3-phospho-1′-myo-inositol-3′,4′-bisphosphate ammonium	Biochemical Assay Reagents
08:0 PI(3,4)P2 (1,2-Dioctanoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,4′-bisphosphate) (ammonium)) is a kind of biochemical reagent.

08:0 PI(3,4)P2 1,2-Dioctanoyl-sn-glycero-3-phospho-1′-myo-inositol-3′,4′-bisphosphate ammonium	Biochemical Assay Reagents
08:0 PI(3,4)P2 (1,2-Dioctanoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,4′-bisphosphate) (ammonium)) is a kind of biochemical reagent.

Cat. No.	Product Name		Classification

HY-157706

PI(3,4)P2 (18:1) ammonium salt		Phospholipids
PI(3,4)P2 (18:1) ammonium salt is a phosphatidylinositol 3 kinase (PI3K) activator. PI(3,4)P2 (18:1) ammonium salt is a polyphosphorylated phosphatidylinositol that promotes the activation of AKT (protein kinase B) by activating PI3K, which affects cell metabolism, growth and survival. PI(3,4)P2 (18:1) ammonium salt is also involved in regulating dynamic changes in the cytoskeleton, affecting cell morphology and movement. PI(3,4)P2 (18:1) ammonium salt can be used in research on the development of cancer, diabetes and cardiovascular disease .

HY-157714

08:0 PI(3,4)P2 1,2-Dioctanoyl-sn-glycero-3-phospho-1′-myo-inositol-3′,4′-bisphosphate ammonium		Phospholipids
08:0 PI(3,4)P2 (1,2-Dioctanoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,4′-bisphosphate) (ammonium)) is a kind of biochemical reagent.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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