351071-62-0
351071-62-0
Chemical Structure
TGX-115
- CAS No.: 351071-62-0
- Formula:C20H20N2O3
- Molecular Weight:336.38
IUPAC Name: 2-morpholino-8-(o-tolyloxy)quinolin-4(1H)-one
InChIKey: FWYYZGLCNUZWPF-UHFFFAOYSA-N
SMILES: O=C1C=C(N2CCOCC2)NC3=C1C=CC=C3OC4=C(C)C=CC=C4
Biological Activity: TGX-115 is a p110β/p110δ-selective, PI3-K inhibitor. TGX-115 blocks p110β-mediated Akt phosphorylation induced by lysophosphatidic acid (LPA) in L6 myotubes, reduces insulin-stimulated PI(3,4)P2 and PIP3 levels in 3T3-L1 adipocytes. TGX-115 can be used for the study of diabetes mellitus[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TGX-115 | 99.31% | TGX-115 is a p110β/p110δ-selective, PI3-K inhibitor. TGX-115 blocks p110β-mediated Akt phosphorylation induced by lysophosphatidic acid (LPA) in L6 myotubes, reduces insulin-stimulated PI(3,4)P2 and PIP3 levels in 3T3-L1 adipocytes. TGX-115 can be used for the study of diabetes mellitus. | ||||||||||||||||||||
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References
- [1]. Fan QW, et al. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell. 2006 May;9(5):341-9. [Content Brief]
- [2]. Knight ZA, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47. [Content Brief]
Keywords
