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PI3K-IN-30

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Nombre del producto Target Áreas de investigación Chemical Structure
  • HY-143404
    PI3K-IN-30
    3 Publications Verification

    		 PI3K Cancer
    PI3K-IN-30 (compound 6d) is a potent PI3K inhibitor with IC50s of 5.1, 136, 30.7 and 8.9 nM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively .
    PI3K-IN-30
  • HY-182368
    PI3Kα-IN-30

    		PI3K Akt Apoptosis Cancer
    PI3Kα-IN-30 is an orally active, selective PI3Kα inhibitor with an IC50 of 2.8 nM. PI3Kα-IN-30 inhibits cancer cell proliferation, as well as the phosphorylation of Akt (S473) and pS6 (S240/244). PI3Kα-IN-30 shows low growth inhibitory activity against normal somatic cell lines at a concentration of 30 μM. PI3Kα-IN-30 induces cancer cell apoptosis and exerts anti-tumor efficacy in xenograft models. PI3Kα-IN-30 can be used for the research of breast cancer .
    PI3Kα-IN-30

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