2 Results for "

PT217

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "PT217" in MCE Product Catalog:

Cat. No.: HY-P9995
CAS No.: 2517973-04-3
Synonyms: JNJ-63733657

Target:  

Tau Protein

Research Areas:  

Neurological Disease

Posdinemab (JNJ-63733657) is a humanized IgG1/κ monoclonal antibody that selectively targets phosphorylated tau (pT217). Posdinemab specifically binds to the pT217+tau epitope rich in the proline domain, blocks tau protein aggregation and seed propagation, and promotes the clearance of extracellular tau species. Posdinemab reduces the levels of free and total p217+tau in cerebrospinal fluid, thereby inhibiting the pathological propagation of tau protein and the formation of neurofibrillary tangles. Posdinemab can be used for the study of progressive supranuclear palsy syndrome and Alzheimer's disease (AD), especially for prodromal or mild AD disease .
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Cat. No.: HY-P991016
CAS No.: 2928515-21-1
Synonyms: PT-217

Target:  

CD47

Research Areas:  

Inflammation/Immunology

Peluntamig (PT-217) is a bispecific antibody targeting DLL3 and CD47. The antibody arms of Peluntamig specifically bind to DLL3 on small cell lung cancer tumor cells while blocking the CD47-SIRPa interaction, thereby effectively stimulating macrophage phagocytosis and inducing NK cell-mediated cytotoxicity. Peluntamig exhibits significant anti-tumor activity against small cell lung cancer and also has favorable safety profiles. Peluntamig can be used in a variety of tumor-related studies including those on small cell lung cancer and L1210 leukemia .
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