1 Result for "

RKN cells

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "RKN cells" in MCE Product Catalog:

Cat. No.: HY-184010
CAS No.: 3101973-42-3
Target:  

Ras ERK

Research Areas:  

Cancer

KRASG12D-IN-8 is an orally active KRAS G12D inhibitor, with a Kd value of 0.003 nM for KRAS G12D and 0.024 nM for KRAS G12V. KRASG12D-IN-8 inhibits the activity of phosphorylated ERK in KRAS-mutated cells. KRASG12D-IN-8 induces tumor regression in ovarian cancer xenograft mouse models. KRASG12D-IN-8 can be used for the research of KRAS-mutated cancers .
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