1 Result for "

SB218078

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "SB218078" in MCE Product Catalog:

5
5 Cited Publications
Cat. No.: HY-107407
CAS No.: 135897-06-2
Purity:  98.30%
Research Areas:  

Cancer

SB-218078 is a potent, selective, ATP-competitive and cell-permeable checkpoint kinase 1 (Chk1) inhibitor that inhibits Chk1 phosphorylation of cdc25C with an IC50 of 15 nM. SB-218078 is less potently inhibits Cdc2 (IC50 of 250 nM) and PKC (IC50 of 1000 nM). SB-218078 causes apoptosis by DNA damage and cell cycle arrest .
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