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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
SK4454
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "SK4454" in MCE Product Catalog:
Cat. No.: HY-179640
Target:
Research Areas:
SK4454 is a selective AURKA PROTAC degrader degrading AURKA with IC50 = 8 nM. MYCN levels in MYCN-amplified neuroblastoma cells and limited by MDR1-mediated efflux. SK4454 efficiently reduced AURKA levels in vivo. SK4454 can be used for neuroblastoma research .
Cat. No.: HY-179643
CAS No.: 2677798-57-9
Research Areas:
Aurora-A ligand 2 is a ligand for the target protein of PROTAC. Aurora-A ligand 2 can be used to synthesize SK4454 (HY-179640) .
Cat. No.: HY-179642
Research Areas:
E3 Ligase Ligand-linker Conjugate 223 is a E3 ligase ligand-linker conjugate that incorporates a CRBN (Thalidomide) ligand and a linker. E3 Ligase Ligand-linker Conjugate 223 can be connected to the target protein ligand to form a PROTAC SK4454 (HY-179640) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
