1 Result for "

SS3091

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "SS3091" in MCE Product Catalog:

Cat. No.: HY-178042
CAS No.: 2756257-56-2
Target:  

Ras Akt ERK

Research Areas:  

Cancer

SS-3091 is a pan-KRas inhibitor active across KRas G12D, KRas G12C, KRas G12V, KRas G12S mutants, with minimal effects on non-KRas-driven cancer cells. SS-3091 binds to the KRas·ARaf interaction interface, destabilizes the complex, and attenuates KRas activity. SS-3091 suppresses phosphorylation of S6K, Akt, and ERK. SS-3091 reduces proliferation and decreases colony formation of cancer cells bearing KRas G12 mutations. SS-3091 can be used for the research of KRas-driven cancers .
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