1 Result for "

SX517

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "SX517" in MCE Product Catalog:

Cat. No.: HY-12927
CAS No.: 1240494-13-6
Purity:  99.88%
Target:  

CXCR

Research Areas:  

Inflammation/Immunology

SX-517 is a dual CXCR2/1 antagonist, containing boronic acid. SX-517 inhibits CXCL1-induced Ca 2+ flux (IC50=38 nM), and antagonizes CXCL8-induced [(35)S]GTPγS binding (IC50=60 nM) and ERK1/2 phosphorylation. SX-517 has significant ability for inflammation suppression, in both humanized polymorphonuclear (PMN) cells and in murine model .
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