2 Results for "

T cell costimulation pathways

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "T cell costimulation pathways" in MCE Product Catalog:

Belatacept
Belatacept
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Cat. No.: HY-108813
CAS No.: 706808-37-9
Purity:  99.30%
Synonyms: BMS 224818; LEA 29Y

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Belatacept (BMS 224818) is a selective T-cell costimulation blocker and a costimulator of the CD28-CD80/86 pathway. Belatacept binds to the CD 80/86 ligand and inhibits CD-28-mediated T cell costimulation and IFN-γ production. Belatacept can be used in studies of immunosuppression in organ transplantation . The component ratio of this product is Active ingredient : Excipients = 1:2.4.
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TNX-1500
TNX-1500
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Cat. No.: HY-P991921

Target:  

TNF Receptor Fc Receptor (FcR)

Research Areas:  

Cardiovascular Disease Endocrinology

TNX-1500 is a crystallizable fragment-modified anti-CD154 antibody. TNX-1500 contains the hu5c8 fragment antigen-binding (Fab) domain from Ruplizumab (HY-P99315) and an IgG4 Fc region engineered to reduce FcγRIIa binding. TNX-1500 has significantly weaker binding affinity to FcγRI, FcγRIIaH, FcγRIIbF, FcγRIIIaF, and FcγRIIIaV compared to hu5c8 (Kd values: 8.7 nM, 7100 nM, 4900 nM, 8000 nM, 6000 nM respectively). TNX-1500 prolongs nonhuman primate renal allograft survival, prolongs nonhuman primate cardiac allograft survival. TNX-1500 can be used for the research of allograft rejection [1] [2].
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