TNX-1500
TNX-1500 is a crystallizable fragment-modified anti-CD154 antibody. TNX-1500 contains the hu5c8 fragment antigen-binding (Fab) domain from Ruplizumab (HY-P99315) and an IgG4 Fc region engineered to reduce FcγRIIa binding. TNX-1500 has significantly weaker binding affinity to FcγRI, FcγRIIaH, FcγRIIbF, FcγRIIIaF, and FcγRIIIaV compared to hu5c8 (Kd values: 8.7 nM, 7100 nM, 4900 nM, 8000 nM, 6000 nM respectively). TNX-1500 prolongs nonhuman primate renal allograft survival, prolongs nonhuman primate cardiac allograft survival. TNX-1500 can be used for the research of allograft rejection[1][2].
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human
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CD40L |
FcγRI 8.7 nM (Kd) |
FcγRIIaH 7100 nM (Kd) |
FcγRIIbF 4900 nM (Kd) |
FcγRIIIaF 8000 nM (Kd) |
FcγRIIIaV 6000 nM (Kd) |
TNX-1500 (500 nM) does not induce platelet activation in cynomolgus monkey or human whole blood when complexed with sCD154[1].
TNX-1500 has significantly weaker binding affinity to FcγRI, FcγRIIaH, FcγRIIbF, FcγRIIIaF, and FcγRIIIaV compared to hu5c8 (KD values: 8.7 nM, 7100 nM, 4900 nM, 8000 nM, 6000 nM respectively)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Lassiter G, et al. TNX-1500, a crystallizable fragment-modified anti-CD154 antibody, prolongs nonhuman primate renal allograft survival. Am J Transplant. 2023;23(8):1171-1181. [Content Brief]
[2]. Miura S, et al. TNX-1500, a crystallizable fragment-modified anti-CD154 antibody, prolongs nonhuman primate cardiac allograft survival. Am J Transplant. 2023;23(8):1182-1193. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TNX-1500 Related Classifications
HY-P991921 Related Classifications
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- TNX-1500
- TNX1500
- TNX 1500
- TNF Receptor
- Fc Receptor (FcR)
- FcγRIIIaF
- allograft rejection
- FcγRIIIaV
- cynomolgus monkey
- antidonor alloantibody elaboration
- nonhuman primates
- platelets
- TEFF/TREG ratio
- FcγRIIaH
- CD40
- cardiac allograft vasculopathy
- regulatory T cells
- sCD154
- kidney transplantation
- chronic rejection
- FcγRI
- CAV
- nonhuman primate heart allotransplant models
- human whole blood
- ABO blood type-compatible
- CD154
- FcγRIIbF
- effector T cells
- kidney allograft rejection
- T cell costimulation pathways
- MHC-mismatched
- Inhibitor
- inhibitor
- inhibit