1 Result for "

TCL6148

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "TCL6148" in MCE Product Catalog:

Cat. No.: HY-P11929
TCL6148 is a ferroptosis inducer targeting GOT1, with a KD of 25.84 μM for GOT1. TCL6148 inhibits the viability of renal cell carcinoma 786-O and A498 cells, with IC50 values of 7.896 μM and 7.468 μM, respectively. TCL6148 induces ferroptosis by increasing Fe 2+, ROS and lipid peroxidation, reducing GSH and inhibiting the GOT1/GPX4 pathway; it also inhibits proliferation and migration of RCC cells, enhances cellular sensitivity to Sunitinib (HY-10255A) and suppresses the growth of RCC xenograft tumors . TCL6148 can be used in research on renal cell carcinoma and ferroptosis .
loading...
    loading...