1 Result for "

TPP-9476

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "TPP-9476" in MCE Product Catalog:

Cat. No.: HY-P992032
Synonyms: BAY-943 antibody

Target:  

Interleukin Related

Research Areas:  

Cancer

TPP-9476 (BAY-943 antibody) is an anti-human IL3RA (CD123) monoclonal antibody with human IL3RA Kd of 11 nM and cynomolgus monkey IL3RA Kd of 16 nM. TPP-9476 binds specifically to human and cynomolgus monkey IL3RA, undergoes target-dependent internalization into lysosomes of IL3RA-positive cells.TPP-9476 exerts antiproliferative effects in IL3RA-expressing acute myeloid leukemia and classical Hodgkin lymphoma cells, reduces tumor burden, improves survival, and induces complete tumor remission in relevant xenograft mouse models .
loading...
    loading...