1 Result for "

UB221

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "UB221" in MCE Product Catalog:

Cat. No.: HY-P991592
CAS No.: 2755114-30-6

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

UB-221 is a humanized IgG1 monoclonal antibody inhibitor targeting IgE. UB-221 significantly decreases IgE synthesis by stabilization of membrane-bound CD23 on B lymphocytes and inhibits FcԑRI-mediated basophil activation and degranulation. UB-221 reduces IgE level in cynomolgus macaques and human IgE (ε, κ)-transgenic (hIGHE-knockin) mice. UB-221 can be used for asthma and chronic spontaneous urticaria (CSU) research .
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