1 Result for "

VTX-0811

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "VTX-0811" in MCE Product Catalog:

Cat. No.: HY-P991432

Target:  

TNF Receptor NF-κB c-Myc

Research Areas:  

Cancer

VTX-0811 is a human IgG4 monoclonal antibody (mAb) targeting PSGL1/CD162. VTX-0811 up-regulates TNF-α/NF-κB and chemokine-mediated signaling and down-regulates oxidative phosphorylation, fatty acid metabolism, and Myc signaling pathways. VTX-0811 increases the proportion of CD8+ T cells among infiltrating T cells. VTX-0811 has antitumor activity in a humanized mouse PDX model of melanoma .
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