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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
Veliparib
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "Veliparib" in MCE Product Catalog:
51
51
Cat. No.: HY-105253
CAS No.: 912444-01-0
Target:
Research Areas:
PARP-2/1-IN-2 (Compound 4a), the enantiomer of Veliparib (HY-10129), is a potent PARP inhibitor with Kis of 2 and 5 nM against PARP-2 and PARP-1, respectively. PARP-2/1-IN-2 has an EC50 of 3 nM in a cell based assay of PARP activity .
Cat. No.: HY-10129R
CAS No.: 912444-00-9
Synonyms: ABT-888 (Standard)
Target:
Research Areas:
Veliparib (Standard) is the analytical standard of Veliparib. This product is intended for research and analytical applications. Veliparib (ABT-888) is a potent PARP inhibitor, inhibiting PARP1 and PARP2 with Kis of 5.2 and 2.9 nM, respectively .
Cat. No.: HY-161517
CAS No.: 2659357-95-4
PARP1-IN-20 (compound 19A10) is a potent inhibitor of PARP1, with the IC50 of 4.62 nM and has similar low PARP-Trapping effect compared with Veliparib (HY-10129), IC50 (MDA-MB-436) >100 μM .
Cat. No.: HY-10130R
CAS No.: 912445-05-7
Synonyms: ABT-888 dihydrochloride (Standard)
Target:
Research Areas:
Veliparib (dihydrochloride) (Standard) is the analytical standard of Veliparib (dihydrochloride) (HY-10130). This product is intended for research and analytical applications. Veliparib (dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Kis of 5.2 nM and 2.9 nM in cell-free assays, respectively.
Cat. No.: HY-130646
CAS No.: 2472645-27-3
iVeliparib-AP6 is a proteolysis-targeting chimera (PROTAC) molecule designed based on Veliparib (HY-10129), which targets PARP1/2. The DC50s of iVeliparib-AP6 for inducing the degradation of PARP1 and PARP2 are 36 nM and 63 nM, respectively, and its IC50s are 69 nM and 21 nM, respectively. iVeliparib-AP6 contains a Veliparib-based PARP inhibitor warhead linked to a CRBN E3 ligase binder; it uses Thalidomide (HY-14658) as a ligand to recruit CRBN E3 ubiquitin ligase and exerts the PARP2 degradation mechanism .
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Protocols
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