1 Result for "

X213

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "X213" in MCE Product Catalog:

Cat. No.: HY-P991358
Synonyms: LFA-102; X213

Research Areas:  

Cancer

XOMA-213 (LFA-102; X213) is a human monoclonal antibody (mAb) targeting the prolactin receptor (PRLR), with a Kd value of 2 nM against the human target. XOMA-213 blocks PRL-induced cell proliferation and inhibits the activation of multiple PRLR ligands, including PRL and human growth hormone (hGH). XOMA-213 suppresses PRL-induced phosphorylation of Stat5, Akt and ERK1/2 in cells. XOMA-213 induces tumor regression, delays disease progression, and inhibits PRLR signaling as well as tumor growth. XOMA-213 can be used in research related to breast cancer .
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