1 Result for "

YF452

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "YF452" in MCE Product Catalog:

Cat. No.: HY-120200
CAS No.: 1951466-83-3
Target:  

VEGFR

Research Areas:  

Cardiovascular Disease Cancer

YF-452 is a potent inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2). YF-452 remarkably inhibits the migration, invasion and tube-like structure formation of human umbilical vein endothelial cells (HUVECs) with little toxicity. YF-452 inhibits VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal regulated kinase (ERK), focal adhesion kinase (FAK) and Src. YF-452 is a potential antiangiogenic agent candidate for cancer research .
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