1951466-83-3
Chemical Structure
YF-452
- CAS No.: 1951466-83-3
- Formula:C24H26BrN3O
- Molecular Weight:452.39
IUPAC Name: 1-(9-(4-bromobenzyl)-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2-(pyrrolidin-1-yl)ethan-1-one
InChIKey: WIRUYQFUVBBWPT-UHFFFAOYSA-N
SMILES: BrC1=CC=C(CN(C2=C3C=CC=C2)C4=C3CCN(C4)C(CN5CCCC5)=O)C=C1
Biological Activity: YF-452 is a potent inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2). YF-452 remarkably inhibits the migration, invasion and tube-like structure formation of human umbilical vein endothelial cells (HUVECs) with little toxicity. YF-452 inhibits VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal regulated kinase (ERK), focal adhesion kinase (FAK) and Src. YF-452 is a potential antiangiogenic agent candidate for cancer research[1].
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YF-452 | YF-452 is a potent inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2). YF-452 remarkably inhibits the migration, invasion and tube-like structure formation of human umbilical vein endothelial cells (HUVECs) with little toxicity. YF-452 inhibits VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal regulated kinase (ERK), focal adhesion kinase (FAK) and Src. YF-452 is a potential antiangiogenic agent candidate for cancer research. | |||||||||||||||||||||
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Keywords
