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3 Results for "
YM150
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "YM150" in MCE Product Catalog:
Synonyms: YM150
Target:
Research Areas:
Darexaban (YM150) is a potent, selective and orally active factor Xa (FXa) inhibitor with an IC50 of 54.6 nM. Darexaban shows high selectivity against other related serine proteases, such as trypsin, thrombin, and kallikrein. Darexaban has anticoagulant and antithrombotic effects .
Cat. No.: HY-135541
CAS No.: 365462-24-4
Synonyms: YM150 maleate
Target:
Research Areas:
Darexaban maleate (YM150 maleate) is a direct factor Xa inhibitor with activity in preventing venous thromboembolism. The major metabolite of Darexaban maleate in humans is Darexaban glucitol, which acts pharmacologically. The glucitolation reaction of Darexaban maleate is mainly catalyzed by UGT1A9 and UGT1A10 in the human liver and intestine. The K(m) value of Darexaban maleate glucitolation in the liver is greater than 250 μM, while in the intestine it exhibits substrate inhibition kinetics with a K(m) value of 27.3 μM. The unbound K(m) value of Darexaban maleate is significantly reduced by the influence of fatty acid-free bovine serum albumin in both HLM and UGT1A9 .
Cat. No.: HY-19866
CAS No.: 432029-12-4
Synonyms: YM-222714
Target:
Research Areas:
Darexaban glucuronide (YM-222714) is a active metabolite of darexaban (YM150). Darexaban glucuronide has an oral activity and antithrombotic effect .
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Protocols
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